Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice
Identifieur interne : 005A87 ( Main/Exploration ); précédent : 005A86; suivant : 005A88Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice
Auteurs : Kanta Subbarao [États-Unis] ; Josephine Mcauliffe [États-Unis] ; Leatrice Vogel [États-Unis] ; Gary Fahle [États-Unis] ; Steven Fischer [États-Unis] ; Kathleen Tatti [États-Unis] ; Michelle Packard [États-Unis] ; Wun-Ju Shieh [États-Unis] ; Sherif Zaki [États-Unis] ; Brian Murphy [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- ARN viral (analyse), ARN viral (génétique), Animaux, Anticorps antiviraux (immunologie), Femelle, Immunisation passive, Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Réplication virale, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- analyse : ARN viral.
- anatomopathologie : Poumon.
- génétique : ARN viral, Virus du SRAS.
- immunologie : Anticorps antiviraux, Poumon, Syndrome respiratoire aigu sévère, Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Animaux, Coronavirus, Femelle, Immunisation passive, Réplication virale, Souris, Anticorps neutralisant, Neutralisation, Prévention, Réplication, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Tests de neutralisation, Voie respiratoire, Animal, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animal, Animals, Antibodies, Viral (immunology), Coronavirus, Female, Immunization, Passive, Lung (immunology), Lung (pathology), Lung (virology), Mice, Mice, Inbred BALB C, Microbiology, Mouse, Neutralization, Neutralization Tests, Neutralizing antibody, Prevention, RNA, Viral (analysis), RNA, Viral (genetics), Replication, Respiratory tract, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Virology, Virus Replication.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Viral.
- genetics : SARS Virus.
- immunology : Lung, SARS Virus, Severe Acute Respiratory Syndrome.
- pathology : Lung.
- physiology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Female, Immunization, Passive, Mice, Mice, Inbred BALB C, Neutralization Tests, Virus Replication.
Abstract
Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.
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Le document en format XML
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Subbarao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Fahle, Gary" sort="Fahle, Gary" uniqKey="Fahle G" first="Gary" last="Fahle">Gary Fahle</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Microbiology Service, Clinical Center, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Steven" sort="Fischer, Steven" uniqKey="Fischer S" first="Steven" last="Fischer">Steven Fischer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Microbiology Service, Clinical Center, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Tatti, Kathleen" sort="Tatti, Kathleen" uniqKey="Tatti K" first="Kathleen" last="Tatti">Kathleen Tatti</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia 30333</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Georgia 30333</wicri:noRegion></affiliation></author><author><name sortKey="Packard, Michelle" sort="Packard, Michelle" uniqKey="Packard M" first="Michelle" last="Packard">Michelle Packard</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia 30333</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Georgia 30333</wicri:noRegion></affiliation></author><author><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia 30333</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Georgia 30333</wicri:noRegion></affiliation></author><author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia 30333</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Georgia 30333</wicri:noRegion></affiliation></author><author><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland 20892</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>Coronavirus</term><term>Female</term><term>Immunization, Passive</term><term>Lung (immunology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microbiology</term><term>Mouse</term><term>Neutralization</term><term>Neutralization Tests</term><term>Neutralizing antibody</term><term>Prevention</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (genetics)</term><term>Replication</term><term>Respiratory tract</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Virology</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>ARN viral (génétique)</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Femelle</term><term>Immunisation passive</term><term>Poumon (anatomopathologie)</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Tests de neutralisation</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lung</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Immunization, Passive</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Virus Replication</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Femelle</term><term>Immunisation passive</term><term>Réplication virale</term><term>Souris</term><term>Anticorps neutralisant</term><term>Neutralisation</term><term>Prévention</term><term>Réplication</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term><term>Tests de neutralisation</term><term>Voie respiratoire</term><term>Animal</term><term>Microbiologie</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></noRegion><name sortKey="Fahle, Gary" sort="Fahle, Gary" uniqKey="Fahle G" first="Gary" last="Fahle">Gary Fahle</name><name sortKey="Fischer, Steven" sort="Fischer, Steven" uniqKey="Fischer S" first="Steven" last="Fischer">Steven Fischer</name><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name><name sortKey="Packard, Michelle" sort="Packard, Michelle" uniqKey="Packard M" first="Michelle" last="Packard">Michelle Packard</name><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><name sortKey="Tatti, Kathleen" sort="Tatti, Kathleen" uniqKey="Tatti K" first="Kathleen" last="Tatti">Kathleen Tatti</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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